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KMID : 0383820090660040324
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Tuberculosis and Respiratory Diseases
2009 Volume.66 No. 4 p.324 ~ p.328
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A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Chemotherapy in a Patient with Non-Small-Cell Lung Cancer
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Lee Kyung-Joo
Lee Sung-Yong
Lee Sang-Yeub
Kim Je-Hyeong
Shin Chol
Shim Jae-Jeong
In Kwang-Ho
Kang Kyung-Ho
Yoo Se-Hwa
Moon Jae-Young
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Abstract
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The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic
phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.
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KEYWORD
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Inappropriate ADH syndrome, Non-small-cell Lung carcinoma, Hyponatremia, Carboplatin
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